A Patient With Tumor Lysis Syndrome
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چکیده
Tumor lysis syndrome (TLS) is a potentially life-threatening metabolic disorder characterized by an elevated uric acid level, elevated serum potassium and phosphorus levels, and a decreased calcium level. Most often seen 12 to 72 hours after administration of systemic chemotherapy for a hematologic malignancy, TLS occasionally may be present prior to the start of therapy. Hematologic malignancies of concern include those that have a high proliferative rate, such as Burkitt’s lymphoma, lymphoblastic lymphoma (LBL), and B–acute lymphoblastic leukemia (B-ALL). Patients with ALL, acute myelogenous leukemia (AML), or chronic lymphocytic leukemia (CLL) who have a high WBC counts could be at risk. Lower-risk patients include those who have indolent lymphomas. Patients with diffuse large-cell lymphoma (DLCL) would be considered at intermediate risk for TLS.[1]
منابع مشابه
The Efficacy of Single Dose Rasburicase in Prevention or Treatment of Tumor Lysis Syndrome in Children
Background: Tumor lysis syndrome (TLS) is a major metabolic complication in patients with malignancy after initiation of chemotherapy or spontaneously without treatment. The role of Rasburicase (a recombinant urate-oxidase enzyme) in prevention and treatment of TLS has been demonstrated in recent years. We aimed to investigate the efficacy of a single dose of rasburicase in reducing the risk of...
متن کاملThe Prevalence of Tumor Lysis Syndrome in Children and Adolescents with Cancer in Hamedan Province, Iran
Background: Tumor lysis syndrome caused by widespread tumor cell damage may lead to electrolyte imbalances and express as metabolic disturbance causing clinical abnormalities. Patients and Methods: All patients younger than 16 years with documented malignancy candidate for chemotherapy, in Hamedan province of Iran were enrolled. Results: Out of 69 cancer patients the laboratory form of tumor ...
متن کاملFrequency of Tumor Lysis Syndrome in Aggressive and Slow Introduction Chemotherapy in Children with ALL
Abstract Background Tumor Lysis Syndrome (TLS) is an oncologic emergency that results from massive lysis of malignant cells. The incidence of TLS depends on the risk factors, such as baseline hyperuricemia, bulky tumor burden, elevated serum LDH, and elevated WBC. The objectives of the present study were to assess frequency of Tumor Lysis Syndrom in children with ALL in two methods of inducti...
متن کاملAcute renal failure due to renal lymphomatous infiltration as the initial manifestation
A male patient with acute renal failure (ARF) due to large B-cell non-Hodgkin lymphoma infiltration of kidney is presented. The diagnosis was suspected because of coincidence of ARF and tumor lysis syndrome non-responsive to conservative renal therapies. A renal biopsy confirmed diagnosis and appropriate chemotherapy led to complete improvement of renal function.
متن کاملIdentification of children with acute lymphoblastic leukemia at low risk for tumor lysis syndrome
Background and Objective: Tumor lysis syndrome (TLS) could occur before, during or after the initiation of chemotherapy in patients with cancers especially those with hematologic malignancies. This study was designed to determine the prevalence and predictors of TLS in children with Acute Lymphoblastic Lymphoma (ALL) and to develop a sensitive prediction rule to identify patients at low risk of...
متن کاملTumor lysis syndrome in a patient with ovarian yolk sac tumor
•Tumor lysis syndrome is an oncologic emergency with profound metabolic derangements.•Germ cell tumors with large disease burden increase the risk for tumor lysis syndrome.•Herein we present a case of tumor lysis syndrome prior to initiation of cytotoxic chemotherapy for ovarian yolk sac tumor.
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